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Alex Karev’s major romantic relationships on Grey’s Anatomy are with Izzie Stevens, Rebecca Pope, Lexie Grey and Jo Wilson. Izzie and Jo are his defining long-term partners: he marries both, then leaves Jo and reunites with Izzie in the story explaining his season 16 departure.
Who has Alex Karev dated?
The four major relationships are Izzie Stevens, Rebecca Pope, Lexie Grey and Jo Wilson. They are not all the same kind of relationship: Izzie and Jo become marriages, while Rebecca and Lexie are earlier, more complicated involvements.
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| 1 |
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Grey’s Anatomy Complete Series 1-17 (94-Disc) | $194.25 | Buy on Amazon |
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Grey's Anatomy: Season 2 (Uncut) | $7.89 | Buy on Amazon |
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Grey's Anatomy: Season 1 | $9.78 | Buy on Amazon |
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Greys Anatomy Season 3 | $17.77 | Buy on Amazon |
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Grey's Anatomy: The Complete Fourth Season | $17.89 | Buy on Amazon |
- Izzie Stevens: an on-and-off romance that leads to marriage and, later, a reunion.
- Rebecca Pope: an earlier, complicated relationship.
- Lexie Grey: an earlier relationship after Alex and Izzie’s romance fractures.
- Jo Wilson: a friendship that develops into a central romance and marriage.
This is a guide to Alex’s major romantic storylines, not a complete list of every hookup or brief encounter. A comprehensive inventory of casual involvements is not established by the cited retrospectives.
Alex and Izzie: an on-and-off romance and reunion
Alex and Izzie’s relationship is marked by breaks and reconciliations before they marry. TV Guide’s retrospective describes the relationship as on-and-off and explains that the season 16 departure story reveals Alex left to be with Izzie and their children. Shondaland also includes their marriage in its guide to the show’s major romances.
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Alex and Jo: friends who become partners
Alex and Jo’s relationship grows out of friendship. ABC’s official character feature describes them as friends before they become the couple known as “Jolex.” They marry before Alex leaves, making Jo a central partner in his story even though his departure ultimately takes him back to Izzie.
Rebecca and Lexie: earlier, complicated relationships
Rebecca Pope is an earlier, complicated involvement rather than a lasting endgame partnership. The available retrospective does not establish a precise duration, so it is more accurate to describe the relationship without assigning it one.
Rank #2
- Condition: Used, Very Good
- Format: DVD
- Box set; Color; NTSC; Closed-captioned
Alex also dates Lexie Grey after his relationship with Izzie fractures. This is an earlier romance, distinct from the marriages that define his relationships with Izzie and Jo.
Independent reader supportYour contribution helps us test, update, and keep practical guides available for everyone.How Alex’s relationships fit together
| Partner | What the relationship becomes | Place in Alex’s story |
|---|---|---|
| Izzie Stevens | On-and-off romance; marriage; reunion | Alex leaves to be with Izzie and their children in his season 16 departure story. |
| Jo Wilson | Friends-to-romance; marriage | A central partnership before Alex leaves. |
| Rebecca Pope | Complicated involvement | An earlier relationship; duration is not established by the cited retrospective. |
| Lexie Grey | Earlier relationship | Dates Alex after his romance with Izzie fractures. |
For the official framing of Alex and Jo’s transition from friends to a couple, see ABC’s Alex Karev character feature. TV Guide recounts Alex and Izzie’s relationship and season 16 reunion, while Shondaland’s romance watch guide covers their marriage.
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Best Value
- Condition: New
- Format: DVD
- Box set; Color; DVD; Widescreen; NTSC
Rank #4
- Condition: Used, Very Good
- Format: DVD
- Surround Sound; NTSC; Closed-captioned; Subtitled
Rank #3
- Condition: Used, Very Good
- Format: DVD
- Closed-captioned; Color; Dolby; DVD; Widescreen; NTSC
Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on Amazon at the time of purchase will apply.
