Several stars have spoken publicly about Ozempic or other weight-management medicines, but their accounts are not interchangeable: some named Ozempic, while others discussed an unnamed prescription or a broader conversation about obesity treatment. Here is what each person said, where the remarks appeared, and what those comments do—and do not—establish.
What Oprah Winfrey has said—and what she did not name
In a December 2023 interview with People, as reported by CBS News, Oprah Winfrey said she had used a medication for weight management. The report did not identify the prescription as Ozempic. Winfrey described the availability of medication as “relief, like redemption, like a gift,” and said it was not something to hide or be ridiculed for.
In a 2024 program whose transcript was published by the FDA, Winfrey discussed weight and weight-management choices while naming Ozempic, Wegovy, Mounjaro and Zepbound in the broader conversation. Her participation in that program does not show that she—or every other person featured—used Ozempic. The transcript is available from the FDA.
Stars who said they tried or used Ozempic
Amy Schumer: stopped after feeling ill
Prevention reported that Schumer said on Watch What Happens Live with Andy Cohen in June 2023 that she had tried Ozempic and stopped because she felt unwell. “I was one of those people that felt so sick and couldn’t play with my son,” she said, according to Prevention. That is her account of her experience, not a prediction of how another person will respond.
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Sharon Osbourne: said she had lost more than she wanted
In remarks to the Daily Mail in November 2023, as recounted by Prevention, Osbourne said: “I’ve lost 42 pounds and I can’t afford to lose any more.” The number is her reported personal account, not a general result to expect from the medication. Prevention also reported that she later told the U.K. program Loose Women she did not regret using it, while describing difficulty putting weight back on. These are remarks reported by an outlet, rather than a transcript reproduced here.
Tracy Morgan: joked about appetite changes
Prevention reported that Morgan said on Today in 2023 that he had obtained Ozempic by prescription and that it reduced his appetite. His line—“It cuts my appetite in half. Now I only eat half a bag of Doritos”—was a joke, not a clinical measure of the drug’s effect. In a 2026 article, Novant Health also repeated the joke and reported that Morgan later joked he had “out-ate Ozempic.” Neither line should be read as evidence about expected outcomes. See Prevention and Novant Health.
Chelsea Handler: described an account involving semaglutide
Prevention reported that Handler said on the Call Her Daddy podcast in 2023 that a doctor gave her semaglutide without her realizing it was Ozempic. She said she stopped taking it and considered the situation irresponsible. This is Handler’s description of her own experience; it is not evidence about prescribing practices generally. The remarks are recounted by Prevention.
Ozempic and Wegovy are not interchangeable in FDA labeling
Both Ozempic and Wegovy contain semaglutide, but they are distinct branded products with different FDA-labeled uses. The official 2025 Ozempic label lists improving glycemic control in adults with type 2 diabetes and certain cardiovascular and kidney risk reductions for specified adults with type 2 diabetes. The 2025 Wegovy label includes chronic weight management for indicated patients. The labels do not support describing Ozempic itself as FDA-approved for weight loss simply because Wegovy’s labeling includes weight management. Consult the current prescribing information for each product: Ozempic label and Wegovy label.
How to read celebrity accounts responsibly
These public remarks differ in what they can establish. Some speakers named Ozempic and described firsthand use; Winfrey’s 2023 interview, by contrast, referred to an unnamed weight-management medication. Other comments describe appetite changes, feeling ill, or difficulty regaining weight. They are personal anecdotes, with different sources and dates—not evidence that a medicine is safe, effective, or suitable for a particular reader.
For product indications, use the FDA labeling rather than celebrity stories. Whether a medicine is appropriate for an individual depends on clinical circumstances that this roundup cannot assess; it is not personal medical advice.
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