Christina Applegate said she sometimes lies in bed screaming from pain associated with multiple sclerosis (MS), describing “the sharp pains, the ache, the squeezing.” She made the remarks on the November 5, 2024 episode of her MeSsy podcast, as reported by ABC News the next day. Her account is personal testimony: MS symptoms and pain differ from one person to another.
What Christina Applegate said about her pain
On MeSsy, the podcast she co-hosts with Jamie-Lynn Sigler, Applegate described episodes when she would “lay in bed screaming.” She named “the sharp pains, the ache, the squeezing,” and said symptoms in her hands could make it hard to hold her phone or remote or open bottles. ABC News reported her comments on November 6, 2024, following the episode’s release on November 5. ABC News’ report also recalled an earlier remark Applegate made on Good Morning America in March 2024: “I’m in excruciating pain, but I’m just used to it now.”
Those statements describe what Applegate experiences; they do not establish the cause of each symptom or amount to a clinical assessment.
MS pain does not look the same for everyone
The National Multiple Sclerosis Society describes different pain patterns that can occur with MS. Neuropathic pain involves changes in sensation, which may feel burning, tingling, or like an electric shock. Musculoskeletal pain can be associated with weakness, altered gait, spasticity, mobility limitations, posture, or falls. A person may experience more than one pattern, and management can differ depending on the cause. These categories provide general context, not an explanation of Applegate’s specific symptoms or a treatment recommendation. The Society’s overview of pain in MS discusses these differences.
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The National Institute of Neurological Disorders and Stroke explains that MS involves damage to myelin in the central nervous system and can include symptoms such as pain and fatigue. Symptoms vary among people with MS. NINDS’ multiple sclerosis overview provides general background.
What Applegate has shared since the podcast interview
In a first-person extract from her memoir published by The Guardian on March 1, 2026, Applegate wrote about substantial pain and exhaustion, difficulty moving her arm far enough to reach a bedside phone or water, and difficulty walking across a room. She also recounted being diagnosed in 2021 while filming the third season of Dead to Me. These are her descriptions of her own life, not evidence of what everyone with MS experiences. Read the memoir extract in The Guardian.
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Applegate also made the variation in pain explicit in the extract: “Some of us with MS have a raft of pain; some don’t. I have a lot of it.” The Associated Press reported that You with the Sad Eyes: A Memoir was released in March 2026 and covers her life, including living with MS. The Associated Press’ coverage of the memoir provides publication context.
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