Rosie O’Donnell has reportedly said she lost about 60 pounds after starting Mounjaro around the time she was diagnosed with type 2 diabetes. That is her account, as reported in July 2026—not a verified medical record or a prediction of what another person might lose.
What Rosie O’Donnell said about her weight loss
Us Weekly, reporting on a People interview on July 23, 2026, quoted O’Donnell saying she had lost about 60 pounds and was “stunned how it quieted the food noise.” The report said she began taking Mounjaro around the time of her type 2 diabetes diagnosis. These details are attributed to O’Donnell through the published interview coverage, rather than independently confirmed health records. Us Weekly’s July 23 account.
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What she reportedly said about her dose and side effects
In Us Weekly’s July 28, 2026 account of her podcast appearance, O’Donnell reportedly described taking 2.5 mg for a year, then 5 mg for a year, followed by 7.5 mg for nearly a year. She said she wanted to increase slowly and reported no side effects, adding: “I like doing it at a slow pace. I like how it feels that I’m not sick, that I’ve never had any kind of side effects.” This is her personal history, not a dosing plan or advice for others. Us Weekly’s July 28 account.
What Mounjaro is approved to treat in the United States
The U.S. prescribing label, updated July 29, 2026, identifies Mounjaro as tirzepatide injection and indicates it, alongside diet and exercise, to improve blood sugar control in adults and pediatric patients aged 10 and older with type 2 diabetes. The Mounjaro brand is not labeled in the United States as a general weight-loss treatment. DailyMed’s current Mounjaro label.
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The label gives a starting dose of 2.5 mg injected under the skin once weekly, with an increase to 5 mg after four weeks. It is information about the labeled regimen—not a recommendation to start, change, or copy a dose. A prescriber determines whether the medicine and any dose change are appropriate for an individual.
Side effects and safety information
O’Donnell’s reported lack of side effects does not mean Mounjaro is side-effect-free. The label lists nausea, diarrhea, decreased appetite, vomiting, constipation, indigestion (dyspepsia), and abdominal pain among common adverse reactions. It also identifies more serious concerns, including severe gastrointestinal reactions, pancreatitis, low blood sugar when used with insulin or insulin secretagogues, allergic reactions, kidney injury related to dehydration, diabetic retinopathy complications, gallbladder disease, and aspiration concerns during anesthesia or deep sedation. Tirzepatide delays stomach emptying and can affect the absorption of oral medicines. Ask a clinician or pharmacist about individual risks and other medicines. DailyMed’s Mounjaro label.
The label carries a boxed warning because thyroid C-cell tumors occurred in rats; whether this applies to humans is unknown. Mounjaro is contraindicated for people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2). A healthcare professional can assess whether the medicine is suitable in light of a person’s medical history.
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Why celebrity results are not a reliable forecast
A reported outcome from one person cannot show what caused the weight change or predict the results, risks, or tolerability another person will experience. O’Donnell’s account is not clinical evidence, and her reported dose history should not be used to guide treatment. Anyone considering a medication for diabetes or weight management should discuss their goals, diagnosis, options, and monitoring with a qualified clinician.
What to know about compounded or unapproved versions
The FDA says unapproved versions of GLP-1 medicines have not undergone its review for safety, effectiveness, and quality before marketing. It says compounded drugs should be used only when a patient’s medical needs cannot be met by an FDA-approved drug, and advises patients to get a prescription from a doctor and fill it at a state-licensed pharmacy. FDA guidance on unapproved GLP-1 drugs.
As of May 31, 2026, FDA had received 990 adverse-event reports associated with compounded semaglutide and more than 730 associated with compounded tirzepatide. The agency cautions that reports may be undercounted and do not establish that a medicine caused each reported event. These figures are reports, not rates of risk.
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